Tissue Engineering at the Micro-Scale
نویسندگان
چکیده
The possibility to replace damaged or diseased organs with arti®cial tissues engineered from a combination of living cells and biocompatible scaffolds is becoming a reality through multidisciplinary efforts. A number of critical components within this effort are being facilitated by microfabrication and MEMS approaches, including research tools to elucidate mechanisms which control cellular behavior as well as development of methods to manufacture cellular scaffolds at ever higher resolutions. This article reviews recent advances in tissue engineering that have been facilitated by interaction with the microfabrication community. We highlight the potential opportunities for microfabrication to make to the development of mainstream medical therapies for tissue replacement. Abbreviations. CAD, computer-aided design; ECM, extracellular matrix; PMMA, polymethyl methacrylate; PDMS, polydimethyl siloxane; PLA polylactic acid; PLGA, polylactic (co-glycolic) acid; SFF, solid freeform fabrication; TEMP, tissue engineered medical product.
منابع مشابه
CFD Study on Hydrogen-Air Premixed Combustion in a Micro Scale Chamber
This paper reports a CFD modeling study to investigate the hydrogen-air mixture combustion in a micro scale chamber. Nine species with nineteen reversible reactions were considered in the premixed combustion model. The effect of operational and geometrical conditions including; combustor size, wall conductivity, reactant flow rates and hydrogen feed splitting on combustion stabilit...
متن کاملMeasuring Performance, Estimating Most Productive Scale Size, and Benchmarking of Hospitals Using DEA Approach: A Case Study in Iran
Background and Objectives: The goal of current study is to evaluate the performance of hospitals and their departments. This manuscript aimed at estimation of the most productive scale size (MPSS), returns to scale (RTS), and benchmarking for inefficient hospitals and their departments. Methods: The radial and non-radial data envelopment analysis (DEA) ap...
متن کاملMicrofluidic spinning of micro- and nano-scale fibers for tissue engineering.
Microfluidic technologies have recently been shown to hold significant potential as novel tools for producing micro- and nano-scale structures for a variety of applications in tissue engineering and cell biology. Over the last decade, microfluidic spinning has emerged as an advanced method for fabricating fibers with diverse shapes and sizes without the use of complicated devices or facilities....
متن کاملA Semi-analytical Solution for Flexural Vibration of Micro Beams Based on the Strain Gradient Theory
In this paper, the flexural free vibrations of three dimensional micro beams are investigated based on strain gradient theory. The most general form of the strain gradient theory which contains five higher-order material constants has been applied to the micro beam to take the small-scale effects into account. Having considered the Euler-Bernoulli beam model, governing equations of motion are w...
متن کاملLength Scale Effect on Vibration Analysis of Functionally Graded Kirchhoff and Mindlin Micro-Plates
In this paper, the modified couple stress theory is used to study vibration analysis of functionally graded rectangular micro-plates. Considering classical and first order plate theories, the couple governing equations of motion are obtained by using the Hamilton’s principle. Considering an assumed mode method, the accurate size dependent natural frequencies are established for simply supported...
متن کاملThe Effect of Micro Turbulence on Quartz Flotation Rate
In this research, the effect of micro turbulence on the flotation rate of quartz particles was investigated. The maximum particle Reynolds number (Rep) was obtained at 60.25 with a particle size of -500+420 µm, impeller speed of 900 rpm, bubble surface area flux of 10.21 1/s and micro scale turbulence size of 162 µm. When the micro turbulence size was equal to the particle size, ...
متن کامل